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Target
Nucleoprotein
Ligand
BDBM614636
Substrate
n/a
Meas. Tech.
TBD
EC50
25.0±n/a nM
Citation
 BARRETT, M; COCKERILL, GS; GOOD, J; AVERY, CA; COCHRANE, EJ; JONES, SP; ONIONS, ST; WARNER, AJ BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION US Patent  US20230270751 Publication Date 8/31/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM614636
Synonyms:
2-(2,6-Difluorophenyl)-N-[(3S)-9-fluoro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide | US20230270751, Example 196
Type:
Small organic molecule
Emp. Form.:
C28H20F3N5O3
Mol. Mass.:
531.4853
SMILES:
Fc1cccc2c1NC(=O)[C@@H](NC(=O)c1c3OCCCn3nc1-c1c(F)cccc1F)N=C2c1ccccc1 |wD:10.11,c:35,(2.25,.55,;2.25,2.09,;.92,2.86,;.92,4.4,;2.25,5.17,;3.59,4.4,;3.59,2.86,;4.79,1.9,;6.29,2.24,;7.25,1.04,;6.96,3.63,;8.5,3.63,;9.27,4.96,;8.5,6.3,;10.81,4.96,;11.71,3.72,;11.39,2.21,;12.54,1.18,;14,1.66,;14.32,3.16,;13.18,4.19,;13.18,5.73,;11.71,6.21,;11.24,7.67,;9.73,7.99,;8.7,6.85,;9.26,9.46,;10.29,10.6,;11.79,10.28,;12.27,8.82,;13.77,8.5,;6.29,5.02,;4.79,5.36,;4.45,6.86,;2.97,7.31,;2.63,8.82,;3.76,9.86,;5.23,9.41,;5.58,7.91,)|
Structure:
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