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Target
Nucleoprotein
Ligand
BDBM614637
Substrate
n/a
Meas. Tech.
TBD
EC50
97.0±n/a nM
Citation
 BARRETT, M; COCKERILL, GS; GOOD, J; AVERY, CA; COCHRANE, EJ; JONES, SP; ONIONS, ST; WARNER, AJ BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION US Patent  US20230270751 Publication Date 8/31/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM614637
Synonyms:
(5R)-2-(4- Ethylsulfonyl-2- fluorophenyl)-N-[(3S)- 9-fluoro-2-oxo-5- phenyl-1,3-dihydro- 1,4-benzodiazepin-3- yl]-5-methyl-6,7- dihydro-5H- pyrazolo[5,1- b][1,3]oxazine-3- carboxamide | US20230270751, Example 197
Type:
Small organic molecule
Emp. Form.:
C31H27F2N5O5S
Mol. Mass.:
619.638
SMILES:
CCS(=O)(=O)c1ccc(-c2nn3CC[C@@H](C)Oc3c2C(=O)N[C@H]2N=C(c3ccccc3)c3cccc(F)c3NC2=O)c(F)c1 |t:25|
Structure:
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