Reaction Details Report a problem with these data
Target
Nucleoprotein
Ligand
BDBM614641
Substrate
n/a
Meas. Tech.
TBD
EC50
49.0±n/a nM
Citation
 BARRETT, M; COCKERILL, GS; GOOD, J; AVERY, CA; COCHRANE, EJ; JONES, SP; ONIONS, ST; WARNER, AJ BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION US Patent  US20230270751 Publication Date 8/31/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM614641
Synonyms:
(5R)-2-(1- Ethylsulfonylpiperidin- 4-yl)-N-[(3S)-9-fluoro- 2-oxo-5-phenyl-1,3- dihydro-1,4- benzodiazepin-3-yl]-5- methyl-6,7-dihydro- 5H-pyrazolo[5,1- b][1,3]oxazine-3- carboxamide | US20230270751, Example 201
Type:
Small organic molecule
Emp. Form.:
C30H33FN6O5S
Mol. Mass.:
608.684
SMILES:
CCS(=O)(=O)N1CCC(CC1)c1nn2CC[C@@H](C)Oc2c1C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O |t:28|
Structure:
Search PDB for entries with ligand similarity: