Reaction Details Report a problem with these data
Target
Fatty acid-binding protein, adipocyte
Ligand
BDBM312388
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay
IC50
20.0±n/a nM
Citation
 Buettelmann, B; Ceccarelli, SM; Kuehne, H; Kuhn, B; Neidhart, W; Obst Sander, U; Richter, H Bicyclic thiophenylamide compounds US Patent  US9604977 Publication Date 3/28/2017 
Target
Name:
Fatty acid-binding protein, adipocyte
Synonyms:
A-FABP | AFABP | ALBP | Adipocyte lipid-binding protein | FABP4 | FABP4_HUMAN | Fatty acid binding protein adipocyte | Fatty acid-binding protein 4 | Fatty acid-binding protein 4 (FABP4)
Type:
Enzyme
Mol. Mass.:
14719.23
Organism:
Homo sapiens (Human)
Description:
P15090
Residue:
132
Sequence:
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
  
Inhibitor
Name:
BDBM312388
Synonyms:
3-[3-(3-Cyclopropyl-[1,2,4]oxadiazol-5-yl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-ylcarbamoyl]-bicyclo[2.2.2]oct-2-ene-2-carboxylic acid | US9604977, Example 134
Type:
Small organic molecule
Emp. Form.:
C22H23N3O4S
Mol. Mass.:
425.501
SMILES:
OC(=O)C1=C(C2CCC1CC2)C(=O)Nc1sc2CCCc2c1-c1nc(no1)C1CC1 |t:3,(1.21,-4.41,;2.75,-4.41,;3.52,-5.74,;3.52,-3.07,;2.75,-1.74,;3.52,-.41,;5.06,-.41,;5.83,-1.74,;5.06,-3.07,;3.73,-2.3,;4.86,-1.18,;1.21,-1.74,;.44,-3.07,;.44,-.41,;-1.1,-.41,;-2,-1.65,;-3.47,-1.18,;-4.93,-1.65,;-5.83,-.41,;-4.93,.84,;-3.47,.36,;-2,.84,;-1.23,2.17,;.31,2.17,;.79,3.64,;-.46,4.54,;-1.71,3.64,;2.12,4.41,;3.66,4.41,;2.89,5.74,)|
Structure:
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