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Target
Fatty acid-binding protein, adipocyte
Ligand
BDBM312391
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay
IC50
20.0±n/a nM
Citation
 Buettelmann, B; Ceccarelli, SM; Kuehne, H; Kuhn, B; Neidhart, W; Obst Sander, U; Richter, H Bicyclic thiophenylamide compounds US Patent  US9604977 Publication Date 3/28/2017 
Target
Name:
Fatty acid-binding protein, adipocyte
Synonyms:
A-FABP | AFABP | ALBP | Adipocyte lipid-binding protein | FABP4 | FABP4_HUMAN | Fatty acid binding protein adipocyte | Fatty acid-binding protein 4 | Fatty acid-binding protein 4 (FABP4)
Type:
Enzyme
Mol. Mass.:
14719.23
Organism:
Homo sapiens (Human)
Description:
P15090
Residue:
132
Sequence:
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
  
Inhibitor
Name:
BDBM312391
Synonyms:
3-[3-(3-Trifluoromethyl-[1,2,4]oxadiazol-5-yl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-ylcarbamoyl]-bicyclo[2.2.2]oct-2-ene-2-carboxylic acid | US9604977, Example 137
Type:
Small organic molecule
Emp. Form.:
C20H18F3N3O4S
Mol. Mass.:
453.435
SMILES:
OC(=O)C1=C(C2CCC1CC2)C(=O)Nc1sc2CCCc2c1-c1nc(no1)C(F)(F)F |t:3,(1.21,-4.68,;2.75,-4.68,;3.52,-6.02,;3.52,-3.35,;2.75,-2.02,;3.52,-.68,;5.06,-.68,;5.83,-2.02,;5.06,-3.35,;3.73,-2.58,;4.86,-1.45,;1.21,-2.02,;.44,-3.35,;.44,-.68,;-1.1,-.68,;-2,-1.93,;-3.47,-1.45,;-4.93,-1.93,;-5.83,-.68,;-4.93,.56,;-3.47,.09,;-2,.56,;-1.23,1.9,;.23,2.37,;.23,3.91,;-1.23,4.39,;-2.14,3.14,;1.57,4.68,;2.9,3.91,;.8,6.02,;2.34,6.02,)|
Structure:
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