Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor UFO
Ligand
BDBM313115
Substrate
n/a
Meas. Tech.
PHOSPHO-AKT IN-CELL WESTERN ASSAY
IC50
>20000±n/a nM
Citation
 Goff, D; Zhang, J; Sylvain, C; Singh, R; Holland, S; Yu, J; Heckrodt, TJ; Ding, P Substituted triazoles useful as Axl inhibitors US Patent  US10166216 Publication Date 1/1/2019 
Target
Name:
Tyrosine-protein kinase receptor UFO
Synonyms:
AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN
Type:
Enzyme
Mol. Mass.:
98316.97
Organism:
Homo sapiens (Human)
Description:
P30530
Residue:
894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM313115
Synonyms:
US10166216, Compound 143 | ethyl 4-(5-amino-1-(2-chloropyridin-4-yl)-1H-1,2,4-triazol-3-ylamino)benzoate
Type:
Small organic molecule
Emp. Form.:
C16H15ClN6O2
Mol. Mass.:
358.782
SMILES:
CCOC(=O)c1ccc(Nc2nc(N)n(n2)-c2ccnc(Cl)c2)cc1
Structure:
Search PDB for entries with ligand similarity: