Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 4
Ligand
BDBM182897
Substrate
n/a
Meas. Tech.
Ca2+ Mobilization In Vitro Assay
EC50
187±n/a nM
Citation
 Biemans, B; Guba, W; Jaeschke, G; Ricci, A; Rueher, D; Vieira, E Ethynyl derivatives US Patent  US9676732 Publication Date 6/13/2017 
Target
Name:
Metabotropic glutamate receptor 4
Synonyms:
GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4
Type:
Protein
Mol. Mass.:
101899.95
Organism:
Homo sapiens (Human)
Description:
Q14833
Residue:
912
Sequence:
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
  
Inhibitor
Name:
BDBM182897
Synonyms:
US9676732, 31 6-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-4H-thiazolo[4,5-d]pyrimidine-5,7-dione
Type:
Small organic molecule
Emp. Form.:
C19H9F2N3O2S
Mol. Mass.:
381.355
SMILES:
Fc1cc(cc(F)c1-n1c(=O)[nH]c2ncsc2c1=O)C#Cc1ccccc1 |(2.82,-.77,;1.48,,;.15,-.77,;-1.18,,;-1.18,1.54,;.15,2.31,;.15,3.85,;1.48,1.54,;2.82,2.31,;2.82,3.85,;1.48,4.62,;4.15,4.62,;5.48,3.85,;6.95,4.33,;7.85,3.08,;6.95,1.83,;5.48,2.31,;4.15,1.54,;4.15,,;-2.52,-.77,;-3.85,-1.54,;-5.19,-2.31,;-6.52,-1.54,;-7.85,-2.31,;-7.85,-3.85,;-6.52,-4.62,;-5.19,-3.85,)|
Structure:
Search PDB for entries with ligand similarity: