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Target
Cathepsin S
Ligand
BDBM315278
Substrate
n/a
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
IC50
590±n/a nM
Citation
 Haap, W; Kuehne, H; Mauser, H Piperidine derivatives US Patent  US10172843 Publication Date 1/8/2019 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM315278
Synonyms:
5-(4-Bromophenyl)-3-[1-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]methyl]-4-piperidyl]-1H-imidazol-2-one | US10172843, Example 12
Type:
Small organic molecule
Emp. Form.:
C26H25BrF3N5O
Mol. Mass.:
560.409
SMILES:
Cc1nc([nH]c1CN1CCC(CC1)n1cc([nH]c1=O)-c1ccc(Br)cc1)-c1ccc(cc1)C(F)(F)F
Structure:
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