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Target
Cathepsin S
Ligand
BDBM315283
Substrate
n/a
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
IC50
195±n/a nM
Citation
 Haap, W; Kuehne, H; Mauser, H Piperidine derivatives US Patent  US10172843 Publication Date 1/8/2019 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM315283
Synonyms:
6-Bromo-3-[1-[[2-[4- (trifluoromethyl)phenyl]- 1H-imidazol-5- yl]methyl]-4-piperidyl]- 1,4-dihydroquinazolin-2- one | US10172843, Example 17
Type:
Small organic molecule
Emp. Form.:
C24H23BrF3N5O
Mol. Mass.:
534.372
SMILES:
FC(F)(F)c1ccc(cc1)-c1ncc(CN2CCC(CC2)N2Cc3cc(Br)ccc3NC2=O)[nH]1
Structure:
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