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Target
Cathepsin S
Ligand
BDBM315314
Substrate
n/a
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
IC50
450±n/a nM
Citation
 Haap, W; Kuehne, H; Mauser, H Piperidine derivatives US Patent  US10172843 Publication Date 1/8/2019 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM315314
Synonyms:
3-{1-[2-(3,4-Dichloro- phenyl)-5-methyl-1H- imidazol-4-ylmethyl]- piperidin-4-yl}-7-fluoro- 3,4-dihydro-1H- quinazolin-2-one | US10172843, Example 48
Type:
Small organic molecule
Emp. Form.:
C24H24Cl2FN5O
Mol. Mass.:
488.385
SMILES:
Cc1[nH]c(nc1CN1CCC(CC1)N1Cc2ccc(F)cc2NC1=O)-c1ccc(Cl)c(Cl)c1
Structure:
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