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Target
Cathepsin S
Ligand
BDBM315340
Substrate
n/a
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
IC50
94.0±n/a nM
Citation
 Haap, W; Kuehne, H; Mauser, H Piperidine derivatives US Patent  US10172843 Publication Date 1/8/2019 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM315340
Synonyms:
3-{1-[2-(4- Methanesulfonyl- phenyl)-5-methyl-1H- imidazol-4-ylmethyl]- piperidin-4-yl}-3,4- dihydro-1H-quinazolin- 2-one | US10172843, Example 74
Type:
Small organic molecule
Emp. Form.:
C25H29N5O3S
Mol. Mass.:
479.594
SMILES:
Cc1[nH]c(nc1CN1CCC(CC1)N1Cc2ccccc2NC1=O)-c1ccc(cc1)S(C)(=O)=O
Structure:
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