Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 2
Ligand
BDBM11160
Substrate
BDBM11156
Meas. Tech.
Dipeptidyl Peptidase Inhibition Assay
IC50
>100000±n/a nM
Citation
Kim, D; Wang, L; Beconi, M; Eiermann, GJ; Fisher, MH; He, H; Hickey, GJ; Kowalchick, JE; Leiting, B; Lyons, K; Marsilio, F; McCann, ME; Patel, RA; Petrov, A; Scapin, G; Patel, SB; Roy, RS; Wu, JK; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem 48:141-51 (2005) [PubMed] Article
More Info.:
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:
Protein
Mol. Mass.:
54339.29
Organism:
Homo sapiens (Human)
Description:
Q9UHL4
Residue:
492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
Inhibitor
Name:
BDBM11160
Synonyms:
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[3,4-a]pyrazin-7-yl]butan-1-one hydrochloride | Sitagliptin Analog 13 | Triazolopiperazine Analogue 25
Type:
Small organic molecule
Emp. Form.:
C16H16F5N5O
Mol. Mass.:
389.3232
SMILES:
N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F |r|