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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM614895
Substrate
n/a
Meas. Tech.
RORgamma Reporter Assay (Gal4)
EC50
0.600±n/a nM
Citation
 Schrøder Glad, S; Sarvary, I; Gouliaev, AH; Franch, T; Nielsen, SJ; Stasi, LP; Erra Solà, M; Taboada Martínez, L; Taltavull Moll, J; Caturla Javaloyes, JF; Pagès Santacana, LM COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS US Patent  US20230271937 Publication Date 8/31/2023 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM614895
Synonyms:
A7-54 rac-2-((3R,4R)-4-(((6- (cyclopropyl(4-(1,1,1,3,3,3- hexafluoro-2-hydroxypropan-2- yl)benzyl)amino)-5- fluoropyrimidin-4- yl)amino)methyl)-3- hydroxypiperidin-1-yl)acetamide | US20230271937, Example A7-54 | US20230271937, Example A7-54-1
Type:
Small organic molecule
Emp. Form.:
C25H29F7N6O3
Mol. Mass.:
594.525
SMILES:
NC(=O)CN1CC[C@@H](CNc2ncnc(N(Cc3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)C3CC3)c2F)[C@H](O)C1 |r|
Structure:
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