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Target
Receptor-type tyrosine-protein kinase FLT3 [D835H]
Ligand
BDBM319752
Substrate
n/a
Meas. Tech.
FLT3 Kinase assay
Kd
120±0.0 nM
Citation
 Czardybon, W; Brzózka, K; Galezowski, M; Windak, R; Milik, M; Zawadzka, M; Guzik, P; Wincza, E; Prokop, M; Wiklik, K; Sabiniarz, A; Cholody, WM; Horvath, R; Rzymski, T Benzimidazole derivatives as kinase inhibitors US Patent  US10174013 Publication Date 1/8/2019 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [D835H]
Synonyms:
CD135 | FL cytokine receptor | FLK2 | FLT3 | FLT3(D835H) | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (D835H) | STK-1 | STK1 | Stem cell tyrosine kinase 1 | Tyrosine Kinase FLT3 Mutant (D835H)
Type:
n/a
Mol. Mass.:
112912.18
Organism:
Homo sapiens (Human)
Description:
P36888 D835H
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARHIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM319752
Synonyms:
US10174013, Example 1A | US10174013, Example 1X | US10174013, Example 1Y
Type:
Small organic molecule
Emp. Form.:
C13H15Br2N5O2
Mol. Mass.:
433.099
SMILES:
CCn1c(nc2c(c(Br)c(Br)cc12)[N+]([O-])=O)N1CCNCC1
Structure:
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