Target

Ligand

Substrate

Meas. Tech.

Carbonic Anhydrase Enzyme Inhibition Assay

Ki

3±n/a nM

Citation

 Scozzafava, A; Supuran, CT Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem 43:3677-87 (2000) [PubMed]  Article Copy BDB DOI

More Info.:

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Name:

Interstitial collagenase

Synonyms:

CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)

Type:

Enzyme

Mol. Mass.:

54010.26

Organism:

Homo sapiens (Human)

Description:

P03956

Residue:

469

Sequence:

MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM11354

Synonyms:

Hydroxamate 35 | N-Pentafluorophenylsulfonyl-N-4-nitrobenzyl-glycine hydroxamate | N-hydroxy-2-{[(4-nitrophenyl)methyl](2,3,4,5,6-pentafluorobenzene)sulfonamido}acetamide

Type:

Small organic molecule

Emp. Form.:

C15H10F5N3O6S

Mol. Mass.:

455.313

SMILES:

ONC(=O)CN(Cc1ccc(cc1)N(=O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM11446

Synonyms:

AcProLeuGly-S-LeuLeuGlyOEt | MMP Thioester Substrate

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: