Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM321270
Substrate
n/a
Meas. Tech.
Binding Assay to Sigma Receptors
Ki
19.0±n/a nM
Citation
 Melnyk, P; Vermersch, P; Carato, P; Oxombre-Vanteghem, B; Zephir, H; Donnier-Marechal, M Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases US Patent  US10179761 Publication Date 1/15/2019 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM321270
Synonyms:
N-[3-(isoindolin-2-yl)methylamino)propyl]-4-chlorobenzamide | US10179761, Compound 3.1.15
Type:
Small organic molecule
Emp. Form.:
C19H22ClN3O
Mol. Mass.:
343.85
SMILES:
Clc1ccc(cc1)C(=O)NCCCNCN1Cc2ccccc2C1
Structure:
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