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Target
Bromodomain-containing protein 9 [134-239]
Ligand
BDBM321419
Substrate
n/a
Meas. Tech.
IC50 measurements for inhibitors using BRD9 AlphaLisa Binding Assay
IC50
46.0±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10183009 Publication Date 1/22/2019 
Target
Name:
Bromodomain-containing protein 9 [134-239]
Synonyms:
BRD9 | BRD9 (aa 134-239) | BRD9_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12286.22
Organism:
Homo sapiens (Human)
Description:
Q9H8M2[134-239]
Residue:
106
Sequence:
AENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSK
  
Inhibitor
Name:
BDBM321419
Synonyms:
6-[(E)-but-2-enyl]-4-[3-methoxy-5-(morpholine-4-carbonyl)-2-pyridyl]-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-one | US10183009, Example 103
Type:
Small organic molecule
Emp. Form.:
C23H26N4O4
Mol. Mass.:
422.4769
SMILES:
COc1cc(cnc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)N1CCOCC1
Structure:
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