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Target
Bromodomain-containing protein 9 [134-239]
Ligand
BDBM321429
Substrate
n/a
Meas. Tech.
IC50 measurements for inhibitors using BRD9 AlphaLisa Binding Assay
IC50
3.00±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10183009 Publication Date 1/22/2019 
Target
Name:
Bromodomain-containing protein 9 [134-239]
Synonyms:
BRD9 | BRD9 (aa 134-239) | BRD9_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12286.22
Organism:
Homo sapiens (Human)
Description:
Q9H8M2[134-239]
Residue:
106
Sequence:
AENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSK
  
Inhibitor
Name:
BDBM321429
Synonyms:
(E)-1-(4-(6-(but-2-en-1-yl)-2-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-2-chlorobenzoyl)piperidine-4-carboxamide | US10183009, Example 113
Type:
Small organic molecule
Emp. Form.:
C25H27ClN4O3
Mol. Mass.:
466.96
SMILES:
C\C=C\Cn1cc(-c2ccc(C(=O)N3CCC(CC3)C(N)=O)c(Cl)c2)c2cc(C)[nH]c2c1=O
Structure:
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