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Target
Tyrosine-protein kinase SYK
Ligand
BDBM322719
Substrate
n/a
Meas. Tech.
Inhibition of Enzymatic Syk Kinase Activity
IC50
<10±n/a nM
Citation
 Venkatesan, A; Smith, RA; Subramanya, H; Potluri, V; Panigrahi, SK; Basetti, V; Kunta, K Pyrimido-pyridazinone compounds and methods of use thereof US Patent  US10183944 Publication Date 1/22/2019 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM322719
Synonyms:
2-(azepan-1-yl)-4-((4-(2-(piperazin-1- yl)ethoxy)phenyl)amino)pyrimido[4,5- d]pyridazin-5(6H)-one hydrochloride | US10183944, Example 107 | US10183944, Example 89 | US10647720, Ex. # 107
Type:
Small organic molecule
Emp. Form.:
C24H32N8O2
Mol. Mass.:
464.5633
SMILES:
O=c1[nH]ncc2nc(nc(Nc3ccc(OCCN4CCNCC4)cc3)c12)N1CCCCCC1
Structure:
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