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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323029
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
33.0±n/a nM
Citation
Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent US10183947 Publication Date 1/22/2019
More Info.:
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Inhibitor
Name:
BDBM323029
Synonyms:
(1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5- yl)benzoyl]-N-(1-methyl-5-sulfamoyl-1H- pyrazol-4-yl)cyclohexanecarboxamide | US10183947, Example 13 | US10508119, Example 13 | US11001589, Example 13 | US11691978, Example 13
Type:
Small organic molecule
Emp. Form.:
C22H26N6O4S
Mol. Mass.:
470.545
SMILES:
Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1S(N)(=O)=O |r|