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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323049
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
170±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323049
Synonyms:
4-[({(1R,2R and 1S,2S)-2-[2-Chloro-4-(3- methyl-1H-pyrazol-5-yl)benzoyl] cyclohexyl}carbonyl)amino]-1-methyl-1H- pyrazole-5-carboxamide | US10183947, Example 32 | US10508119, Example 32
Type:
Small organic molecule
Emp. Form.:
C23H25ClN6O3
Mol. Mass.:
468.936
SMILES:
Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cnn(C)c2C(N)=O)c(Cl)c1 |w:17.19,12.12|
Structure:
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