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Target
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Ligand
BDBM190870
Substrate
n/a
Meas. Tech.
Raf IC50 Assay
Temperature
298.15±n/a K
IC50
840±n/a nM
Comments
extracted
Citation
 Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent  US9670203 Publication Date 6/6/2017 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Synonyms:
C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
38958.87
Organism:
Homo sapiens (Human)
Description:
PV3805, from Invitrogen
Residue:
343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM190870
Synonyms:
US9670203, Compound 1.73 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)-3-((1S,1aS,6bS)-5-((7-oxo-5,6,7,8-tetrahydro-1, 8-naphthyridin-4-yl)oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)urea
Type:
Small organic molecule
Emp. Form.:
C32H33F3N6O4
Mol. Mass.:
622.6374
SMILES:
CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1 |r|
Structure:
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