Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 4
Ligand
BDBM325574
Substrate
n/a
Meas. Tech.
Cell-Based Assay
EC50
1.30±n/a nM
Citation
 Nirogi, R; Mohammed, AR; Yarlagadda, S; Ravella, SR; Shinde, AK; Kambhampati, R; Roayapalley, PK; Jayarajan, P; Bhyrapuneni, G; Patnala, SM; Ravula, J; Jasti, V Heteroaryl compounds as 5-HT4 receptor ligands US Patent  US9636335 Publication Date 5/2/2017 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:
Enzyme
Mol. Mass.:
43767.54
Organism:
Homo sapiens (Human)
Description:
Q13639
Residue:
388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
  
Inhibitor
Name:
BDBM325574
Synonyms:
6-Chloro-8-[5-(1-cyclobutyl-piperidin-4-yl)-[1,3,4]oxadiazol-2-yl]-chroman-5-ylamine | US9636335, 14
Type:
Small organic molecule
Emp. Form.:
C20H25ClN4O2
Mol. Mass.:
388.891
SMILES:
Nc1c(Cl)cc(-c2nnc(o2)C2CCN(CC2)C2CCC2)c2OCCCc12
Structure:
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