Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM50134645
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
207±n/a nM
Citation
 Peng, J; Sun, P; Lan, J; Gu, C; Li, X; Liu, B; Han, C; Hu, Q; Jin, F; Dong, Q; Cao, G Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof US Patent  US9637484 Publication Date 5/2/2017 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM50134645
Synonyms:
CHEMBL3746426 | US9637484, 5
Type:
Small organic molecule
Emp. Form.:
C17H19NO4S
Mol. Mass.:
333.402
SMILES:
COCCOc1ccc2nccc(SC3(CCC3)C(O)=O)c2c1
Structure:
Search PDB for entries with ligand similarity: