Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM326044
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
164±n/a nM
Citation
 Peng, J; Sun, P; Lan, J; Gu, C; Li, X; Liu, B; Han, C; Hu, Q; Jin, F; Dong, Q; Cao, G Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof US Patent  US9637484 Publication Date 5/2/2017 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM326044
Synonyms:
1-((6-(2-methoxy-2-oxoethoxy)quinolin-4-yl)thio)cyclobutanecarboxylic acid | US9637484, 13
Type:
Small organic molecule
Emp. Form.:
C17H17NO5S
Mol. Mass.:
347.386
SMILES:
COC(=O)COc1ccc2nccc(SC3(CCC3)C(O)=O)c2c1
Structure:
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