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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM193871
Substrate
n/a
Meas. Tech.
LSD1 Histone Demethylase Biochemical Assay
pH
7.5±n/a
IC50
<100±n/a nM
Comments
extracted
Citation
 Wu, L; He, C; Yao, W; Zhang, F Cyclopropylamines as LSD1 inhibitors US Patent  US9670210 Publication Date 6/6/2017 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM193871
Synonyms:
US10174030, Example 11 | US10717737, Example 11 | US11247992, Example 11 | US9670210, Example 11 (5S)-2-(cis-4-Hydroxycyclohexyl)-7-[(3-{[(trans-2-phenylcyclopropyl)amino]methyl}azetidin-1-yl)carbonyl]-2,7-diazaspiro[4.5]decan-1-one
Type:
Small organic molecule
Emp. Form.:
C28H40N4O3
Mol. Mass.:
480.6422
SMILES:
O[C@H]1CCC(CC1)N1CC[C@]2(CCCN(C2)C(=O)N2CC(CNC3CC3c3ccccc3)C2)C1=O |r,wU:10.37,1.0,(1.92,-5.67,;3.01,-4.58,;2.61,-3.1,;3.7,-2.01,;5.19,-2.41,;5.59,-3.89,;4.5,-4.98,;6.28,-1.32,;7.82,-1.32,;8.29,.15,;7.05,1.05,;8.38,1.82,;8.38,3.36,;7.05,4.13,;5.71,3.36,;5.71,1.82,;4.38,4.13,;4.38,5.67,;3.05,3.36,;2.65,1.88,;1.16,2.27,;-.17,1.5,;-1.51,2.27,;-2.84,1.5,;-3.61,2.84,;-4.38,1.5,;-5.71,.73,;-7.05,1.5,;-8.38,.73,;-8.38,-.81,;-7.05,-1.58,;-5.71,-.81,;1.56,3.76,;5.8,.15,;4.47,.92,)|
Structure:
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