Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM328267
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay
EC50
<500±n/a nM
Citation
 Irving, M; Shaw, S AMPK-activating heterocyclic compounds and methods for using the same US Patent  US9663496 Publication Date 5/30/2017 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM328267
Synonyms:
6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxyphenyl) piperidin-4- yl)nicotinamide | US10377742, Compound 405 | US9663496, Compound 405
Type:
Small organic molecule
Emp. Form.:
C30H34FN5O3
Mol. Mass.:
531.6211
SMILES:
COc1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1
Structure:
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