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Target
Nuclear receptor ROR-gamma
Ligand
BDBM329710
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
7443±n/a nM
Citation
 Barr, KJ; Maclean, JK; Zhang, H; Beresis, RT; Anthony, NJ; Daniels, M; Lapointe, BT; Sciammetta, N 3-aminocycloalkyl compounds as RORgammaT inhibitors and uses thereof US Patent  US9663522 Publication Date 5/30/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM329710
Synonyms:
2-(1-(1-(2-chloro-6- (trifluoromethyl)benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)azetidin-3- yl)acetic acid | US9663522, 1Q
Type:
Small organic molecule
Emp. Form.:
C19H14ClF3N4O3
Mol. Mass.:
438.788
SMILES:
OC(=O)CC1CN(C1)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccnc12
Structure:
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