Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 E1
Ligand
BDBM329886
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
<10±n/a nM
Citation
 Afroze, R; Bharathan, IT; Ciavarri, JP; Fleming, PE; Gaulin, JL; Girard, M; Langston, SP; Soucy, F; Wong, T; Ye, Y Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme US Patent  US9663525 Publication Date 5/30/2017 
Target
Name:
Ubiquitin-conjugating enzyme E2 E1
Synonyms:
E2 ubiquitin-conjugating enzyme E1 | UB2E1_HUMAN | UBCH6 | UBE2E1
Type:
n/a
Mol. Mass.:
21408.98
Organism:
Homo sapiens (Human)
Description:
P51965
Residue:
193
Sequence:
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
  
Inhibitor
Name:
BDBM329886
Synonyms:
(rac)-((1R,2R,3S,4R)-4-(2-(5-ethylbenzo[b]thiophen-3-yl)pyrazolo[1,5-a]pyrimidin-7- | US10202389, Compound I-094 | US9663525, Compound I-094 | US9796725, Compound I-094
Type:
Small organic molecule
Emp. Form.:
C22H25N5O5S2
Mol. Mass.:
503.594
SMILES:
CCc1ccc2scc(-c3cc4nccc(N[C@@H]5C[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]5O)n4n3)c2c1 |r|
Structure:
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