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Target
Eyes absent homolog 3
Ligand
BDBM50158465
Substrate
n/a
Meas. Tech.
Inhibitory Assay
IC50
8300±n/a nM
Citation
 Hegde, R Use of small molecule inhibitors targeting EYA tyrosine phosphatase US Patent  US9725430 Publication Date 8/8/2017 
Target
Name:
Eyes absent homolog 3
Synonyms:
EYA3 | EYA3_HUMAN | Eyes absent homolog 3 (EYA3)
Type:
Protein
Mol. Mass.:
62648.48
Organism:
Homo sapiens (Human)
Description:
Q99504
Residue:
573
Sequence:
MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSSTIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSEKPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
  
Inhibitor
Name:
BDBM50158465
Synonyms:
(4-hydroxy-3,5-diiodophenyl)(2-methylbenzofuran-3-yl)methanone | CHEMBL389052 | US9725430, Compound 1d | US9962362, Compound 1d
Type:
Small organic molecule
Emp. Form.:
C16H10I2O3
Mol. Mass.:
504.0577
SMILES:
Cc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1
Structure:
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