Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM330362
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
354±n/a nM
Citation
 Kuduk, SD; Liverton, NL; Skudlarek, JW Hydroxy-substituted orexin receptor antagonists US Patent  US9725434 Publication Date 8/8/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM330362
Synonyms:
2-(4-Fluoro-3-{[(3R,6R)- 6-methyl-1-{[2-(2H- 1,2,3-triazol-2-yl) phenyl]carbonyl} piperidin-3-yl] oxy}phenyl) propan-2-ol | US9725434, 20
Type:
Small organic molecule
Emp. Form.:
C24H27FN4O3
Mol. Mass.:
438.4946
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cc(ccc1F)C(C)(C)O
Structure:
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