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Target
Probable G-protein coupled receptor 142
Ligand
BDBM332763
Substrate
n/a
Meas. Tech.
GPR142 Agonist Effect as Measured by IP-1 Assay
EC50
30.1±4.2 nM
Citation
 Hu, ZL; Liu, LZ; Ma, T; Zhang, H; Zhou, J Tetrahydropyranyl benzamide derivatives US Patent  US10196385 Publication Date 2/5/2019 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2
Type:
PROTEIN
Mol. Mass.:
51127.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_985961
Residue:
462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
  
Inhibitor
Name:
BDBM332763
Synonyms:
Cis-(chiral)-N-[2-[5-(1,4- Dimethyl-1H-imidazol-5-yl)- 4H-1,2,4-triazol-3- yl]tetrahydro-2H-pyran-4- yl]-N-methyl-3- (trifluoromethoxy)benzamide, Isomer 1 | US10196385, Example 2
Type:
Small organic molecule
Emp. Form.:
C21H23F3N6O3
Mol. Mass.:
464.4409
SMILES:
CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(OC(F)(F)F)c1 |r|
Structure:
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