Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM333233
Substrate
n/a
Meas. Tech.
Assay for Binding Affinity for Adenosine Receptor A3
Ki
550±n/a nM
Citation
 Lee, J; Kim, S; Kim, D; Ahn, K; Lee, G; Kim, D; Hwang, H Compounds antagonizing A3 adenosine receptor, method for preparing them, and medical-use thereof US Patent  US10196396 Publication Date 2/5/2019 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM333233
Synonyms:
(2S,3R,4S)-2-(8-((2-(3-chlorophenyl)propan-2-yl)amino)-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)tetrahydrothiophene-3,4-diol | US10196396, Compound 28
Type:
Small organic molecule
Emp. Form.:
C18H20ClN5O2S
Mol. Mass.:
405.902
SMILES:
CC(C)(Nc1nccn2c(nnc12)[C@@H]1SC[C@@H](O)[C@H]1O)c1cccc(Cl)c1
Structure:
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