Reaction Details Report a problem with these data
Target
Prostaglandin E synthase
Ligand
BDBM197528
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.000±n/a nM
Citation
 Otsu, H Heterocyclic derivative and pharmaceutical drug US Patent  US9732066 Publication Date 8/15/2017 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM197528
Synonyms:
US9216968, 128 | US9732066, 128
Type:
Small organic molecule
Emp. Form.:
C26H21Cl3N4O3
Mol. Mass.:
543.829
SMILES:
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(Cl)cccc2Cl)cc2[nH]c(nc12)[C@H]1CCCO1 |r|
Structure:
Search PDB for entries with ligand similarity: