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Target
Beta-secretase 1
Ligand
BDBM335427
Substrate
n/a
Meas. Tech.
HTRF FRET Assay
Ki
15.0±n/a nM
Citation
 Walsh, SP; Cumming, JN; He, S; Taoka, BM; Truong, QT; Wu, W C2-carbocyclic iminothiazine dioxides as BACE inhibitors, compositions, and their use US Patent  US9732088 Publication Date 8/15/2017 
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM335427
Synonyms:
8-((6-((3R,6S)-5-amino-6- cyclopropyl-6-(fluoromethyl)- 3-methyl-1,1-dioxido-3,6- dihydro-2H-1,4-thiazin-3-yl)-5- fluoropyridin-2-yl)amino)-1,7- naphthyridine-3-carbonitrile | US9732088, Example 2
Type:
Small organic molecule
Emp. Form.:
C23H21F2N7O2S
Mol. Mass.:
497.52
SMILES:
C[C@]1(CS(=O)(=O)[C@@](CF)(C2CC2)C(N)=N1)c1nc(Nc2nccc3cc(cnc23)C#N)ccc1F |r,c:14|
Structure:
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