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Target
Catenin beta-1 [138-686]
Ligand
BDBM213748
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
Ki
17780±2130 nM
Citation
 Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9738628 Publication Date 8/22/2017 
Target
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Homo sapiens (Human)
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Inhibitor
Name:
BDBM213748
Synonyms:
US9284299, PKF115-584 | US9738628, Compound PKF115-584
Type:
Small organic molecule
Emp. Form.:
C44H38O14
Mol. Mass.:
790.7641
SMILES:
COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(C[C@@H](C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(C[C@@H](C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O |r|
Structure:
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