Target
Catenin beta-1 [138-686]
Ligand
BDBM213761
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
Ki
3140±480 nM
Citation
 Ji, HYu, BZhang, MGuo, W Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9738628 Publication Date 8/22/2017 
Target
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Homo sapiens (Human)
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Inhibitor
Name:
BDBM213761
Synonyms:
US9284299, 12 | US9738628, Compound 12
Type:
Small organic molecule
Emp. Form.:
C9H9N7O
Mol. Mass.:
231.2141
SMILES:
On1nnc2cc(CCc3nn[nH]n3)ccc12
Structure:
Search PDB for entries with ligand similarity: