Reaction Details Report a problem with these data
Target
Histamine receptor H3
Ligand
BDBM200829
Substrate
n/a
Meas. Tech.
Radioligand binding assay
Ki
38.9±0 nM
Citation
 Gao, Z; Hall, D; Stefany, D Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof US Patent  US9533995 Publication Date 1/3/2017 
Target
Name:
Histamine receptor H3
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
48611.84
Organism:
Macaca mulatta (Rhesus macaque)
Description:
Q865E1
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM200829
Synonyms:
2-[2-methyl-6-((2s,3'r)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyridin-3-yl]-2,9-diaza-spiro[5.5]undecan-1-one hydrochloride | US9533995, 9
Type:
Small organic molecule
Emp. Form.:
C24H37N5O
Mol. Mass.:
411.5835
SMILES:
C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCCC3(CCNCC3)C2=O)c(C)n1 |r|
Structure:
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