Reaction Details Report a problem with these data
Target
Histamine receptor H3
Ligand
BDBM200831
Substrate
n/a
Meas. Tech.
Radioligand binding assay
Ki
7.57±0 nM
Citation
 Gao, Z; Hall, D; Stefany, D Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof US Patent  US9533995 Publication Date 1/3/2017 
Target
Name:
Histamine receptor H3
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
48611.84
Organism:
Macaca mulatta (Rhesus macaque)
Description:
Q865E1
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM200831
Synonyms:
2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyridin-3-yl]-2,8-diaza-spiro[4.5]decan-1-one | US9533995, 11
Type:
Small organic molecule
Emp. Form.:
C23H35N5O
Mol. Mass.:
397.5569
SMILES:
C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)n1 |r|
Structure:
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