Reaction Details Report a problem with these data
Target
Histamine receptor H3
Ligand
BDBM200837
Substrate
n/a
Meas. Tech.
Radioligand binding assay
Ki
4.21±0 nM
Citation
 Gao, Z; Hall, D; Stefany, D Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof US Patent  US9533995 Publication Date 1/3/2017 
Target
Name:
Histamine receptor H3
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
48611.84
Organism:
Macaca mulatta (Rhesus macaque)
Description:
Q865E1
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM200837
Synonyms:
2-[2-((2s,3's)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyrimidin-5-yl]-8-oxa-2-aza-spiro[4.5]decan-1-one | US9533995, 16
Type:
Small organic molecule
Emp. Form.:
C21H31N5O2
Mol. Mass.:
385.5031
SMILES:
C[C@H]1CCCN1[C@H]1CCN(C1)c1ncc(cn1)N1CCC2(CCOCC2)C1=O |r|
Structure:
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