Reaction Details Report a problem with these data
Target
Flap endonuclease 1
Ligand
BDBM168744
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
1.000±n/a nM
Citation
 Bacani, GM; Eccles, W; Fitzgerald, AE; Goldberg, SD; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Lee-Dutra, A; Liu, J; McClure, KJ; Meduna, SP; Pippel, DJ; Rosen, MD; Sales, ZS Flap modulators US Patent  US9745328 Publication Date 8/29/2017 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM168744
Synonyms:
US9079866, 134 | US9745328, Compound 134 | US9884878, Compound 134
Type:
Small organic molecule
Emp. Form.:
C22H24FN5O2S
Mol. Mass.:
441.522
SMILES:
N[C@H]1CC[C@H](CC1)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r,wU:4.7,1.0,(-6.16,-5.33,;-5.39,-4,;-6.16,-2.67,;-5.39,-1.33,;-3.85,-1.33,;-3.08,-2.67,;-3.85,-4,;-3.08,,;-3.85,1.33,;-5.18,.56,;-2.52,2.1,;-4.62,2.67,;-6.16,2.67,;-6.93,4,;-6.16,5.33,;-4.62,5.33,;-3.85,4,;-2.31,4,;-1.54,5.33,;,5.33,;.77,4,;,2.67,;.77,1.33,;-1.54,2.67,;2.31,4,;3.08,5.33,;4.62,5.33,;5.39,4,;6.93,4,;4.62,2.67,;3.08,2.67,)|
Structure:
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