Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM13778
Substrate
BDBM12679
Meas. Tech.
Enzyme Inhibition Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
400±n/a nM
Citation
Rai, R; Kolesnikov, A; Sprengeler, PA; Torkelson, S; Ton, T; Katz, BA; Yu, C; Hendrix, J; Shrader, WD; Stephens, R; Cabuslay, R; Sanford, E; Young, WB Discovery of novel heterocyclic factor VIIa inhibitors. Bioorg Med Chem Lett 16:2270-3 (2006) [PubMed] Article
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
Inhibitor
Name:
BDBM13778
Synonyms:
2-[3-(5-carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid | CHEMBL76325 | amidine-containing inhibitor 2
Type:
Small organic molecule
Emp. Form.:
C23H18N4O5
Mol. Mass.:
430.4128
SMILES:
NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(c1)[N+]([O-])=O