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Target
E3 ubiquitin-protein ligase Mdm2 [1-188]
Ligand
BDBM50008819
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence Assay
IC50
<0.100±n/a nM
Citation
 Gonzalez Buenrostro, A; Li, Y; Medina, JC; Olson, SH Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer US Patent  US9758495 Publication Date 9/12/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [1-188]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) | MDM2 | MDM2_HUMAN
Type:
n/a
Mol. Mass.:
21319.18
Organism:
Homo sapiens (Human)
Description:
Q00987[1-188]
Residue:
188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDS
  
Inhibitor
Name:
BDBM50008819
Synonyms:
CHEMBL3236665 | US9758495, 1
Type:
Small organic molecule
Emp. Form.:
C33H36Cl2N2O6S
Mol. Mass.:
659.62
SMILES:
CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](O[C@@](C)(Cc2ccc(cn2)C(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure:
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