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Target
Non-receptor tyrosine-protein kinase TYK2 [871-1187]
Ligand
BDBM348899
Substrate
n/a
Meas. Tech.
TYK2 Inhibition Assay
IC50
>1000±n/a nM
Citation
 Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent  US10206907 Publication Date 2/19/2019 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [871-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 | Non-receptor tyrosine-protein kinase TYK2 (871-1187) | TYK2 | TYK2 (aa 871-1187) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36255.07
Organism:
Homo sapiens (Human)
Description:
P29597[871-1187]
Residue:
317
Sequence:
PHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM348899
Synonyms:
N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide | US10206907, Compound 12 | US10206907, Compound 163
Type:
Small organic molecule
Emp. Form.:
C23H20N4O2
Mol. Mass.:
384.4305
SMILES:
O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1
Structure:
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