Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM204930
Substrate
n/a
Meas. Tech.
Human Complement Factor D Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
32±n/a nM
Comments
extracted
Citation
 Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Randl, SA; Rogel, O; Vulpetti, A Complement pathway modulators and uses thereof US Patent  US9550755 Publication Date 1/24/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM204930
Synonyms:
1-{2-oxo-2-[(1R,3S,5R)-3-{[1-(trifluoromethyl)-1H-pyrazol-3-yl]carbamoyl}-2-azabicyclo[3.1.0]hexan-2-yl]ethyl}-1H-indazole-3-carboxamide | US9550755, example 5
Type:
Small organic molecule
Emp. Form.:
C20H18F3N7O3
Mol. Mass.:
461.3972
SMILES:
NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2ccn(n2)C(F)(F)F)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: