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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM349410
Substrate
n/a
Meas. Tech.
BRD4 AlphaLisa Binding Assay
IC50
18233±n/a nM
Citation
 Romero, FA; Magnuson, SR; Pastor, R; Tsui, VH; Murray, J; Crawford, T; Burdick, DJ; Albrecht, BK; Cote, A; Taylor, AM; Nasveschuck, CG; LeBlanc, Y; Hewitt, MC; Lai, KW; Chen, K Therapeutic compounds and uses thereof US Patent  US10206931 Publication Date 2/19/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM349410
Synonyms:
4-methyl-N-[3-(4-methyl- | US10206931, Example 218
Type:
Small organic molecule
Emp. Form.:
C20H20N6O2
Mol. Mass.:
376.4118
SMILES:
CC1CC(=O)Nc2cccc(C(=O)Nc3cccc(c3)-c3nncn3C)c2N1
Structure:
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