Reaction Details Report a problem with these data
Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM205030
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.3±n/a
IC50
16.0±0 nM
Comments
extracted
Citation
 Demnitz, J; Jorgensen, S Tetrazole derivatives and their use as potassium channel modulators US Patent  US9556132 Publication Date 1/31/2017 
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM205030
Synonyms:
US9556132, 7 | process for preparing 2-(2-{2-[1-(2-fluorophenyl)-1h-1,2,3,4-tetrazol-5-yl]phenyl}phenoxy)acetonitrile
Type:
Small organic molecule
Emp. Form.:
C21H14FN5O
Mol. Mass.:
371.3672
SMILES:
Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1OCC#N
Structure:
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