Reaction Details Report a problem with these data
Target
Atypical chemokine receptor 3
Ligand
BDBM345948
Substrate
n/a
Meas. Tech.
In Vitro Assay
EC50
1.000±n/a nM
Citation
 Guerry, P; Lehembre, F; Pothier, J; Siendt, H CXCR7 receptor modulators US Patent  US10202368 Publication Date 2/12/2019 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM345948
Synonyms:
2-(3-Cyclopropylmethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-yloxy)-N-(2-dimethylamino-ethyl)-N-(2-trifluoromethyl-benzyl)-acetamide | US10202368, Example 23
Type:
Small organic molecule
Emp. Form.:
C28H36F3N3O2
Mol. Mass.:
503.5995
SMILES:
CN(C)CCN(Cc1ccccc1C(F)(F)F)C(=O)COc1cccc2CCN(CC3CC3)CCc12
Structure:
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