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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Ligand
BDBM50242207
Substrate
n/a
Meas. Tech.
Fluorometric Ub-AMC Hydrolysis Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
30000±n/a nM
Comments
extracted
Citation
 Ott, CA; Baljinnyam, B; Zakharov, AV; Jadhav, A; Simeonov, A; Zhuang, Z Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. ACS Chem Biol 12:2399-2407 (2017) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Synonyms:
CGI-70 | UCH-L5 | UCH37 | UCHL5 | UCHL5_HUMAN | Ubiquitin C-terminal hydrolase UCH37 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Ubiquitin thioesterase L5
Type:
PROTEIN
Mol. Mass.:
37597.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109575
Residue:
329
Sequence:
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK
  
Inhibitor
Name:
BDBM50242207
Synonyms:
CHEMBL455364 | Mangiferin
Type:
Small organic molecule
Emp. Form.:
C19H18O12
Mol. Mass.:
438.339
SMILES:
OC[C@H]1O[C@@H](Oc2c(O)cc3oc4cc(O)c(O)cc4c(=O)c3c2O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
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