Reaction Details Report a problem with these data
Target
G protein-activated inward rectifier potassium channel 4
Ligand
BDBM347066
Substrate
n/a
Meas. Tech.
TBD
IC50
14.0±n/a nM
Citation
 Duncia, JV; Gardner, DS; Hynes, J; Macor, JE; Nair, SK; Paidi, VR; Santella, JB; Sarkunam, K; Sistla, RK; Polimera, SR; Wu, H Heteroaryl substituted aminopyridine compounds US Patent  US10202390 Publication Date 2/12/2019 
Target
Name:
G protein-activated inward rectifier potassium channel 4
Synonyms:
CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5
Type:
PROTEIN
Mol. Mass.:
47658.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107914
Residue:
419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
  
Inhibitor
Name:
BDBM347066
Synonyms:
US10202390, Example 21
Type:
Small organic molecule
Emp. Form.:
C24H26ClN9O3
Mol. Mass.:
523.975
SMILES:
COC(=O)N1CCC(n2cc(nn2)-c2cnc(cc2NC2CC2)-c2cnc3cc(Cl)cnn23)[C@](C)(O)C1 |r|
Structure:
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